Post Cardiac Arrest Syndrome

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Tissue Post Cardiac Arrest

Hypoperfusion to the gut during cardiac arrest is an important clinical problem. The inability to control pH during metabolic stress, e.g. ischemia, leads to the disruption or halting of processes vital to balancing cellular metabolism. Alterations in cellular pH have been linked to changes in intramucosal permeability, which may result in the leakage of inflammatory mediators or bacteria, or b...

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Contemporary Reviews in Cardiovascular Medicine Post Cardiac Arrest Syndrome

Out-of-hospital cardiac arrest (OHCA) is a common initial presentation of cardiovascular disease, affecting up to 325 000 people in the United States each year.1 In a recent meta-analysis of 140 000 patients with OHCA, survival to hospital admission was 23.8%, and survival to hospital discharge was only 7.6%.2 In patients who initially achieve return of spontaneous circulation (ROSC) after OHCA...

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Whole-body ischemia and reperfusion due to cardiac arrest and subsequent return of spontaneous circulation constitute post-cardiac arrest syndrome (PCAS), which consists of four syndromes including systemic ischemia/reperfusion responses and post-cardiac arrest brain injury. The major pathophysiologies underlying systemic ischemia/reperfusion responses are systemic inflammatory response syndrom...

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ژورنال

عنوان ژورنال: Circulation

سال: 2011

ISSN: 0009-7322,1524-4539

DOI: 10.1161/circulationaha.110.988725